• Editorial

      Bhugra, Dinesh; Broadway-Horner, Matt; orcid: 0000-0002-8834-7441; Kar, Anindya; orcid: 0000-0003-3319-5433; Pemberton, Max (Informa UK Limited, 2022-09-24)
    • How many practice hours are required to become a registered nurse?

      Garrow, Amanda; Roberts, Debbie; Kenny, Amanda; Leigh, Jacqueline; Borwell, Juliet; Knight, Kate H; Whaley, Victoria; Monks, Rob; Wright, Karen M (Mark Allen Group, 2022-09-22)
    • Are you lookin’ at me? A mixed-methods case study to investigate the influence of coaches’ presence on performance testing outcomes in male academy rugby league players

      Richardson, Ben; Dobbin, Nick; orcid: 0000-0001-7508-1683; White, Christopher; Bloyce, Daniel; Twist, Craig; orcid: 0000-0001-6168-0378 (SAGE Publications, 2022-09-21)
      The study used a mixed-methods approach to examine how the presence of coaches influenced male academy rugby league players’ performance during physical performance testing. Fifteen male rugby players completed two trials of 20 m sprint, countermovement jump and prone Yo-Yo test; one with only the sport scientist present and a second where the sport scientist conducted the battery with both the club's lead strength and conditioning coach, academy manager, and the first team assistant and head coach present. Players and coaches then completed one-to-one semi-structured interviews to explore their beliefs, attitudes and opinions towards physical performance testing. In all tests, the players’ performance was better when the coaches were present compared to when tests were conducted by the sport scientist alone. Interviews revealed performance testing was used by coaches to exercise their power over players to socialise them into the desired culture. Players’ own power was evident through additional effort during testing when coaches were present. Practitioners should ensure consistency in the presence of significant observers during performance testing of male rugby players to minimise their influence on test outcome.
    • Patronage and Power in the Medieval Welsh March: One Family’s Story, by David Stephenson

      Roberts, Sara Elin (Oxford University Press (OUP), 2022-09-08)
    • N-3 fatty acid supplementation mediates lipid profile, including small dense LDL, when combined with statins: a randomized double blind placebo controlled trial.

      Dogay Us, Gediz; Mushtaq, Sohail (2022-09-01)
      Epidemiological and clinical evidence suggests that high-dose intake of omega 3 fatty acids (n-3 FA) have a favorable role in altering serum triglycerides (TG) and non-high density lipoprotein cholesterol (non-HDL-C) when combined with statins in hyperlipidemic patients. Their efficacy in altering low-density lipoprotein cholesterol (LDL-C) particle size is yet to be established. This study evaluated the effects of supplementing 4 g/day Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) on serum blood lipids, including small, dense LDL-C particle concentration, in hyperlipidemic patients receiving stable statin therapy. In this randomized, placebo-controlled, double-blind parallel group study, 44 patients on statin therapy for > 8 weeks with non-HDL-C concentrations above 130 mg/dL were randomized into two groups. For 8 weeks, together with their prescribed statin, the intervention group received 4 g/day EPA + DHA (3000 mg EPA + 1000 mg DHA in ethyl ester form) and the placebo group received 4 g/day olive oil (OO). Measurements of serum non-HDL-C, TG, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), LDL-C (including large - LDL I; intermediate - LDL II; and small - LDL III subclasses), very-low-density lipoprotein cholesterol (VLDL-C) concentration, were taken at baseline and post-intervention. Dietary intake was assessed with a weighed intake, 3-day food diary at week 4. Primary outcome measures were percent change in LDL III, non-HDL-C and LDL particle number. At the end of treatment, the median percent change in serum LDL III concentration was significantly greater in the n-3 FA group plus atorvastatin compared to placebo (- 67.5% vs - 0%, respectively; P < 0.001). Supplementation with n-3 FA plus atorvastatin led to significant reductions in serum non-HDL-C (- 9.5% vs 4.7%, P < 0.01), TG (- 21.5% vs 6.2%, P < 0.001) and VLDL-C (- 36.9% vs 4.0%, P < 0.001) and TC (- 6.6% vs 2.1%, P < 0.001). Between the groups, no significant difference in percent change in the serum concentration of LDL-C, HDL-C, as well as in the LDL I and LDL II subclasses was observed. In this group of hyperlipidemic patients on a stable statin prescription, OM3 plus atorvastatin improved small dense LDL concentrations, non-HDL-C, VLDL-C and TG to a greater extent than atorvastatin alone. Further studies are warranted in this area. This trial was retrospectively registered on 23 May 2019 on ClinicalTrials.gov with ID: NCT03961763. [Abstract copyright: © 2022. The Author(s).]
    • Psychological therapies and non-suicidal self-injury in LGBTIQ in accident and emergency departments in the UK: a scoping review

      Broadway-Horner, Matt; orcid: 0000-0002-8834-7441; Kar, Anindya; orcid: 0000-0003-3319-5433; Pemberton, Max; Ventriglio, Antonio (Informa UK Limited, 2022-08-25)
    • Correction: Wiśniewska et al. Heterospecific Fear and Avoidance Behaviour in Domestic Horses ( Equus caballus ). Animals 2021, 11, 3081

      Wiśniewska, Anna; orcid: 0000-0003-1127-2960; Janczarek, Iwona; orcid: 0000-0001-9032-8840; Wilk, Izabela; orcid: 0000-0001-7958-2303; Tkaczyk, Ewelina; orcid: 0000-0003-4495-7413; Mierzicka, Martyna; Stanley, Christina R.; orcid: 0000-0002-5053-4831; Górecka-Bruzda, Aleksandra; orcid: 0000-0002-2770-2278; email: a.gorecka@igbzpan.pl (MDPI, 2022-08-10)
      The authors wish to make the following correction to this paper [...]
    • Correction: Wiśniewska et al. Heterospecific Fear and Avoidance Behaviour in Domestic Horses (

      Wiśniewska, Anna; orcid: 0000-0003-1127-2960; Janczarek, Iwona; orcid: 0000-0001-9032-8840; Wilk, Izabela; orcid: 0000-0001-7958-2303; Tkaczyk, Ewelina; orcid: 0000-0003-4495-7413; Mierzicka, Martyna; Stanley, Christina R; orcid: 0000-0002-5053-4831; Górecka-Bruzda, Aleksandra; orcid: 0000-0002-2770-2278 (2022-08-10)
      The authors wish to make the following correction to this paper [...].
    • Correction: Wiśniewska et al. Heterospecific Fear and Avoidance Behaviour in Domestic Horses (<i>Equus caballus</i>). <i>Animals</i> 2021, <i>11</i>, 3081.

      Wiśniewska, Anna; orcid: 0000-0003-1127-2960; Janczarek, Iwona; orcid: 0000-0001-9032-8840; Wilk, Izabela; orcid: 0000-0001-7958-2303; Tkaczyk, Ewelina; orcid: 0000-0003-4495-7413; Mierzicka, Martyna; Stanley, Christina R; orcid: 0000-0002-5053-4831; Górecka-Bruzda, Aleksandra; orcid: 0000-0002-2770-2278 (2022-08-10)
      The authors wish to make the following correction to this paper [...].
    • Pentecostalism: A democratizing, liberating force for black women?

      McDonald, Patrice (Informa UK Limited, 2022-08-08)
    • Pentecostalism: A democratizing, liberating force for black women?

      McDonald, Patrice (Informa UK Limited, 2022-08-08)
    • A unique ternary Ce(III)-quercetin-phenanthroline assembly with antioxidant and anti-inflammatory properties.

      Halevas, E; Matsia, S; Hatzidimitriou, A; Geromichalou, E; Papadopoulos, T A; Katsipis, G; Pantazaki, A; Litsardakis, G; Salifoglou, A (2022-07-30)
      Quercetin is one of the most bioactive and common dietary flavonoids, with a significant repertoire of biological and pharmacological properties. The biological activity of quercetin, however, is influenced by its limited solubility and bioavailability. Driven by the need to enhance quercetin bioavailability and bioactivity through metal ion complexation, synthetic efforts led to a unique ternary Ce(III)-quercetin-(1,10-phenanthroline) (1) compound. Physicochemical characterization (elemental analysis, FT-IR, Thermogravimetric analysis (TGA), UV-Visible, NMR, Electron Spray Ionization-Mass Spectrometry (ESI-MS), Fluorescence, X-rays) revealed its solid-state and solution properties, with significant information emanating from the coordination sphere composition of Ce(III). The experimental data justified further entry of 1 in biological studies involving toxicity, (Reactive Oxygen Species, ROS)-suppressing potential, cell metabolism inhibition in Saccharomyces cerevisiae (S. cerevisiae) cultures, and plasmid DNA degradation. DFT calculations revealed its electronic structure profile, with in silico studies showing binding to DNA, DNA gyrase, and glutathione S-transferase, thus providing useful complementary insight into the elucidation of the mechanism of action of 1 at the molecular level and interpretation of its bio-activity. The collective work projects the importance of physicochemically supported bio-activity profile of well-defined Ce(III)-flavonoid compounds, thereby justifying focused pursuit of new hybrid metal-organic materials, effectively enhancing the role of naturally-occurring flavonoids in physiology and disease. [Abstract copyright: Copyright © 2022 Elsevier Inc. All rights reserved.]
    • The kidney matrisome in health, aging and disease.

      Lausecker, Franziska; Lennon, Rachel; Randles, Michael J (2022-07-20)
      Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation, requires the integration of data acquired by both well-established and novel technologies. Owing to its complexity, the extracellular proteome, or matrisome, still holds many secrets and has great potential for the identification of clinical biomarkers and drug targets. The molecular resolution of matrix composition during aging and disease has been illuminated by cutting-edge mass spectrometry-based proteomics in recent years, but there remain key questions about the mechanisms that drive altered matrix composition. Basement membrane components are particularly important in the context of kidney function; and data from proteomic studies suggest that switches between basement membrane and interstitial matrix proteins are likely to contribute to organ dysfunction during aging and disease. Understanding the impact of such changes on physical properties of the matrix, and the subsequent cellular response to altered stiffness and viscoelasticity, is of critical importance. Likewise, the comparison of proteomic datasets from multiple organs is required to identify common matrix biomarkers and shared pathways for therapeutic intervention. Coupled with single cell transcriptomics there is the potential to identify the cellular origin of matrix changes, which could enable cell targeted therapy. This review provides a contemporary perspective of the complex kidney matrisome and draws comparison to altered matrix in heart and liver disease. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.]
    • Football Fandom as a Platform for Digital Health Promotion and Behaviour Change: A Mobile App Case Study.

      Fenton, Alex; orcid: 0000-0001-6102-6288; Cooper-Ryan, Anna Mary; orcid: 0000-0002-8305-8587; Hardey, Mariann Maz; orcid: 0000-0002-1027-0165; Ahmed, Wasim; orcid: 0000-0001-8923-1865 (2022-07-09)
      The last decade has seen a dramatic shift toward the study of fitness surveillance, thanks in part to the emergence of mobile health (mHealth) apps that allow users to track their health through a variety of data-driven insights. This study examines the adoption trends and community mediation of the mobile fitness application 'FanFit', a platform aimed at promoting physical activity among sports fans by creating a fitness app branded to their favourite team for health promotion. Our study looked at the impact of a specially designed mobile app (FanFit) as a digital health intervention for initiating and maintaining physical activity as part of football club membership. Our analysis indicates that app users will adopt healthier behaviours as a result of the app's sense of fan community and behaviour change. The findings reported here are based on an implementation of the FanFit app and, in particular, on those who participated in a more in-depth study ( = 30). These participants were Rangers FC supporters with a mix of genders = 19 males and = 11 females). Focus groups and interviews were conducted with participants to ascertain users' perspectives on the most effective methods for nudging users toward adopting and maintaining a pattern of fitness behaviours. The findings show that the user community was interested in fitness and wanted to live a 'healthy lifestyle,' which was augmented and fuelled by the app's competitive architecture design. Furthermore, the data reveal a new fan-health discourse about a person's developing wants, talents, and identities as embodied beings. We have developed and presented valid links between the use of sports club apps and health programmes. The app could be useful for sports programmes and club providers looking for mHealth applications that provide community support through fan discourse with opportunities for both male and female fans.
    • Dietary Intakes and the Risk of Low Energy Availability in Male and Female Advanced and Elite Rock Climbers.

      Monedero, Javier; orcid: 0000-0003-4509-1658; Duff, Christina; Egan, Brendan (2022-07-08)
      Monedero, J, Duff, C, and Egan, B. Dietary intakes and the risk of low energy availability in male and female advanced and elite rock climbers. J Strength Cond Res XX(X): 000-000, 2022-There is a culture among rock climbers of striving to maintain low body mass and percentage body fat to enhance performance. Diet practices based on this belief might lead to increased risk of low energy availability (LEA) or eating disorders (EDs). Twenty-five advanced or elite rock climbers (male, n = 14; female, n = 11) had body composition measured, completed 4-day food intake and physical activity diaries while wearing an accelerometer and heart rate monitor, and completed the Eating Attitudes Test (EAT)-26 and the Low Energy Availability in Females Questionnaire (LEAF-Q; n = 11 female subjects only). EAT-26 scores of 3.5 (1.8, 7.0) [median (IQR)] and 9.3 ± 6.4 (mean ± SD) for male and female subjects, respectively, indicated low risk of ED in this cohort, but 4 female subjects were at high risk of LEA according to LEAF-Q scores. Suboptimal (<45 kcal·kg·FFM-1·d-1) and LEA (<30 kcal·kg·FFM-1·d-1) were evident in 88 and 28%, respectively, of climbers. However, only the female climbers had energy intakes (1775 ± 351 kcal·d-1) significantly lower than their calculated energy requirements (2056 ± 254 kcal·d-1; p = 0.006). In all subjects, carbohydrate intakes were lower (male subjects: 3.8 ± 1.2 g·kg-1·d-1, p = 0.002; female subjects: 3.4 ± 0.7 g·kg-1·d-1, p < 0.001), and fat intakes were higher (male subjects: 1.6 ± 0.5 g·kg-1·d-1, p < 0.001; female subjects: 1.4 ± 0.4 g·kg-1·day-1, p < 0.001) than current sports nutrition recommendations, and inadequate intakes of calcium, magnesium, and vitamin D were observed. Female subjects specifically had lower than recommended intakes of protein and iron. These results show that advanced and elite rock climbers have a high prevalence of LEA and have a risk of having nutritional deficiencies as result of their diet. [Abstract copyright: Copyright © 2022 National Strength and Conditioning Association.]
    • Can Player Tracking Devices Monitor Changes in Internal Response During Multidirectional Running?

      Oxendale, Chelsea L; orcid: 0000-0002-8805-4868; Highton, Jamie; orcid: 0000-0003-1715-4252; Smith, Grace; orcid: 0000-0001-5100-2928; Twist, Craig; orcid: 0000-0001-6168-0378 (2022-07-07)
      We examined the movement, physiological and muscle function responses to running with and without (i.e. linear) multiple directional changes to understand which measures of external demands better reflected changes in the internal response. Twelve team sport athletes completed a linear and multidirectional running trial during which movement characteristics, oxygen consumption ( ), blood lactate (B[La]) and heart rate (HR) were measured. Isometric peak torque of knee extensors and flexors was also assessed before and after each trial. High speed running distance was higher during the linear trial ( < 0.001), whereas time at high metabolic power ( = 0.046), number of accelerations ( < 0.001), summated HR ( = 0.003) and B[La] ( = 0.002) were higher during the multidirectional trial. Integrated external to internal ratios of high-speed running: summated HR and high-speed running: total were different between multidirectional and linear trials ( ≤ 0.001). Conversely, high metabolic power: summated HR and high metabolic power: total were similar ( ≥ 0.246). Small decrements in knee flexor ( = 0.003) and extensor torque ( = 0.004) were observed after both trials. Time at high metabolic power better reflects the increased internal response during running with more directional changes than high speed running.